AN ONTOLOGICAL APPROACH FOR CREATING A BRASSWARE CRAFT KNOWLEDGE BASE



The chromosome-scale genome assembly for the West Nile vector Culex quinquefasciatus uncovers patterns of genome evolution in mosquitoes

Abstract Background Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes.Anophelinae and Culicinae subfamilies of mosquitoes show striking differences in genome sizes, sex chromosome arrangements, behavior, and ability to transmit pathogens.However, the genomic basis

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Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers

Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers.Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers.However, a novel therapeutic approach is needed to further improve patient outcome with these agent

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